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Jeff was an American guitarist, best known as a founding member of the American thrash metal band Slayer.
Slayer spokeswoman Heidi Robinson-Fitzgerald said Hanneman died Thursday morning of liver failure at a Los Angeles hospital with his wife, Kathy, by his side.
The guitarist had recently begun writing songs with the band in anticipation of recording a new album later this year. He had been slowly recovering from what was believed to be a spider bite that nearly cost him his arm after he failed to seek immediate treatment.